Research

  • OBGYN abstract title "ARID1A Loss Results in Non‐Receptive Endometrium with FOXA2 Deficiency in Endometriosis‐Related Infertility" by Ryan M. Marquadt has been selected for the SRI President’s Plenary Award. This award will be presented at our 66th Annual Scientific Meeting, which will be held in Paris, France, March 12 – 16, 2019.

    The President’s Plenary Awards recognize the four highest ranked abstracts chosen for presentation at the President’s New Investigator Plenary Session. The Society has always sought a means by which to encourage young investigators to present their research at our meeting. The award encourages many young investigators to submit high‐quality abstracts.

  • (Updated October 6th 2020)

    Title/DescriptionSponsorPIAmountStart DateEnd Date
    Familias Fuertes y Saludables (Strong and Healthy Families) Kellogg Foundation Kelly Strutz, PhD
    LeeAnne Roman, PhD
    $67,000 9/1/14 8/31/21
    Strong Beginnings (Healthy Start Initiative – Eliminating Racial/Ethnic Disparities) HRSA - Spectrum Health System Kelly Strutz, PhD
    LeeAnne Roman, PhD
    $202,765 11/1/14 3/31/24
    Family Smoking Cessation in Romania Using Pregnancy as a Window of Opportunity NIH Cristian Meghea, PhD $698,251 12/1/14 11/30/20
    The Role of PPAR in Human Placental Development and Preeclampsia NIH Sascha Drewlo, PhD $1,530,688 7/1/15 3/31/21
    Role of microRNA in the Pathophysiology of Endometriosis NIH - NICHHD Asgi Fazleabas, PhD $1,792,972 4/1/16 1/31/21
    Risk Factors for Early Pregnancy Loss NIH - NICHHD Jae Wook Jeong, PhD $1,607,347 4/10/16 3/31/21
    Reproductive and Developmental Sciences Program T32 Training Grant NIH Keith Latham, PhD
    Asgi Fazleabas, Phd
    $1,485,595 6/1/16 4/30/21
    Subfertility and Assisted Conception Study of Parent and Child Health Outcomes NIH - Dartmouth Stacey Missmer, ScD $220,988 6/23/16 3/31/21
    Molecular Mechanisms of Telomerase Catalysis and its Recruitment to Telomeres NIH Jens Schmidt, PhD $746,999 8/15/16 3/31/21
    Marriott Fund for Clinical Innovation in Endometriosis J. Willard and Alice S. Marriott Foundation Stacey Missmer, ScD $546,755 8/16/16 6/30/21
    Modulation of the Receptive Endometrium and Decidualization by Notch NIH - NICHHD Asgi Fazleabas, PhD $1,609,214 9/12/16 5/31/21
    Integrative Analysis of Genomic, Epigenomic and Phenotypic Data for DiseaseStratification of Endometriosis NIH - University of California San Francisco Stacey Missmer, ScD $235,337 9/26/16 4/30/21
    Assisted Reproduction and Child Health: Risk of Birth Defects, Mortality, and Effect on Grade School Performance NIH Barbara Luke, ScD $2,639,139 9/30/16 5/30/21
    Strong Beginnings: Pay for Success Spectrum Health - MSU Alliance Corporation Richard Leach, MD $1,000,000 7/1/17 6/30/22
    Computational Model of Autophagy-Mediated Survival in Chemoresistant Lung Cancer NIH Jeffrey MacKeigan, PhD $1,424,968 9/1/17 8/31/21
    Mobile Health Intervention for Family Smoking Cessation in Romania NIH Cristian Meghea, PhD $344,468 12/9/17 11/30/20
    Translational Research in Pelvic Pain (TRiPP) Oxford University Stacey Missmer, ScD $31,000 1/1/18 3/31/21
    Defining the role of endometrium in endometriosis-associated ovarian cancer American Cancer Society Michael Wilson, PhD $163,500 1/1/18 6/30/21
    Implementing to sustain: Determining the minimum necessary intervention to maintain a postpartum depression prevention program (ROSE) in clinics providing prenatal services to low-income women National Institute of Mental Health Jennifer Johnson, PhD $1,540,162 1/1/18 12/31/22
    Women's Outcomes Research and Knowledge (WORK) AbbVie Stacey Missmer, ScD $2,956,535 4/1/18 3/31/21
    Defining Mechanistic Targets and Circulating Biomarkers to Therapeutic Response and Resistance to Clinical ATR and Chk1 Inhibitors in High-Grade Ovarian Cancer Henry Jackson Foundation John Risinger, PhD $66,495 7/15/18 7/14/21
    WisE: The goal of the study is to identify unique classifications of endometriosis patients that inform non-invasive diagnostics, response to current treatments, and novel treatment pathways - stratifying discoveries by participant symptom presentation, and for the cases, by surgical and imaging visualized disease characteristics to capture the full heterogeneity of endometriosis. NIH Stacey Missmer, ScD 3,868,014 9/1/18 8/31/23
    Mobile Health Intervention for Family Smoking Cessation in Romania (supplement) NIH Cristian Meghea, PhD $58,946 12/1/18 11/30/20
    Mobile Health Intervention for Family Smoking Cessation in Romania (supplement) NIH Cristian Meghea, PhD $96,194 12/1/18 11/30/20
    Single molecule analysis of telomerase recruitment to telomeres Damon Runyon Cancer Research Foundation Jens Schmidt, PhD $100,000 1/1/19 6/30/21
    An AHEI Dietary Intervention to Reduce Pain in Women with Endometriosis National Insitute of Nursing Research Stacey Missmer, ScD $91,203 2/11/19 12/31/20
    Harnessing biomarker and phenotypic diversity among adolescents and women with endometriosis to advance personalized medicine for diagnosis and pain remediation NIH Stacey Missmer, ScD $504,027 4/1/19 3/31/21
    Infertility History and Chronic Disease Profile NIH Stacey Missmer, ScD $3,276,321 5/15/19 4/30/24
    PARP inhibition and non-BRCA DNA damage repair mutation MI Ovarian Cancer Alliance John Risinger, PhD
    Jose Teixeira, PhD
    $50,000 6/1/19 12/31/20
    The role of cholesterol metabolism in recurrent endometrial cancer Mary Kay Foundation Jae Wook Jeong, PhD $100,000 7/1/19 6/30/21
    The pathophysiology of progesterone resistance in endometriosis Society for Reproductive Investigation Tae Hoon Kim, PhD $20,000 7/1/19 6/30/21
    Development of RNAi based sFLT1-targeting therapeutics for treatment of Preeclampsia NIH - University of Massachusetts Asgerally Fazleabas, PhD $96,236 7/1/19 6/30/21
    In Vitro Fertilization Outcomes After Cancer NIH Barbara Luke, ScD $370,550 8/5/19 7/31/23
    Defining the role for descending pain modulation and reward-aversion processes towards the development of chronic pain in endometriosis US Dept of the Army - Boston Children's Hospital Stacey Missmer, ScD $75,124 8/15/19 8/14/22
    Innate Immune Mechanisms at the Maternal-Fetal Interface in Normal and Superovulatory Pregnancy NIH - Rutgers University Ripla Arora, PhD $54,509 8/21/19 7/31/24
    Patient-specific targeting of uterine fibroids NIH - NICHD Jose Teixeira, PhD $2,469,234 8/28/19 4/30/24
    The role of chromatin remodeling and cell signaling in endometriosis etiology NIH - NICHD Ronald Chandler, PhD
    Asgi Fazleabas, PhD
    $430,375 9/1/19 8/31/21
    Using affinity based proteomics to identify diagnostic and plasma biomarkers for endometriosis US Dept of the Army - Brigham and Women's Hospital Stacey Missmer, ScD $41,402 9/1/19 8/31/22
    Peer navigation for individuals with serious mental illness leaving jail   NIH Maji Debena, PhD $714,202 9/1/19 8/31/22
    Therapeutically targeting novel mechanisms for precision oncology Erasca Jeffrey MacKeigan, PhD $547,750 1/1/20 12/31/21
    Alliance for Innovation on Maternal Health Community Care Initiative (AIM CCI) HRSA - Spectrum Health System Cristian Meghea, PhD $106,921 4/1/20 9/30/24
    Myometrial stem cells NIH Jose Teixeira, PhD $430,375 6/1/20 5/31/22
    Nonsteroidal treatment for endometriosis   Society for Reproductive Investigation Jae Wook Jeong, PhD $20,000 7/1/20 6/30/21
    Stem cell epigenetics in uterine fibroids NIH Jose Teixeira, PhD $464,333 7/1/20 6/30/22
    2020 Jean P. Schultz Biomedical Research Endowment Award MSU CHM Sascha Drewlo, PhD $30,000 7/1/20 6/30/21
    Effects of Non-steroidal Anti-inflammatory Drugs on Uterine 3D Structure and Pregnancy Outcomes March of Dimes Ripla Arora, PhD $150,000 7/1/20 6/30/22
    A Smartphone Intervention for Pregnancy Smoking Cessation with Peer Support NIH Cristian Meghea, PhD $380,865 8/6/20 7/31/22
    IPT for major depression following perinatal loss NIH - NICHHD Jennifer Johnson, PhD $3,358,550 8/7/20 7/31/25
    Molecular mechanisms of endometrial progesterone resistance NIH Jae Wook Jeong, PhD $2,657,839 8/15/20 4/30/25
    The role of ARID1A in endometriosis-related infertility NIH Ryan Marquardt $108,907 8/16/20 8/15/23
    Meeting women where they are: Multilevel intervention addressing racial disparities in maternal morbidity and mortality NIH Jennifer Johnson, PhD $3,944,351 9/14/20 4/30/25
    Single-molecule Analysis of the DNA Damage Response in Living Cells NIH Jens Schmidt, PhD $2,137,302 9/30/20 5/31/25
    Strong Beginnings : Care Improvement for African American and Latina Women MDHHS Lee Anne Roman, PhD $634,434 10/1/20 9/30/21
    State Opioid Relief for Use Disorders MDHHS Kelly Strutz, PhD
    Cara Poland, MD
    $810,786 10/1/20 9/30/21
  • The number of opioid-related deaths in Michigan has hit an all-time high, requiring the resources of the state’s three major research universities and one of its largest health systems to tackle the problem.

    Read Full Article on MSUToday

  • Bin Gu PhD

    Biography

    Bin Gu, Ph.D. received his BS degree in Bio-technology and his Ph.D. degree in Cell Biology from Zhejiang University in Hangzhou, China. He completed postdoctoral training at the Hospital for Sick Children in Canada from 2013 to 2020 in the Program of Developmental and Stem Cell Biology. He is now an Assistant Professor in the Department of Obstetrics, Gynecology and Reproductive Biology within the College of Human Medicine.

    Research

    The focus of my research is investigating the molecular mechanisms regulating early embryo development, infertility and genetic disease. My Lab develop new genome engineering technology to generate mouse models for complex mutations to model human diseases. We study them use cutting-edge technologies, such as live imaging and in-vivo genetic engineering, to understand the mechanism and develop new treatments for human diseases.

    Areas of expertise

    • Early embryo development
    • Live imaging
    • Genome engineering
    • Mouse models of human genetic diseases

    NCBI Publications 

  • Cristian Meghea PhD

    BIOGRAPHY

    Cristian Meghea, Ph.D. is an NIH-funded Associate Professor in the Department of Obstetrics, Gynecology and Reproductive Biology at Michigan State University. His expertise is in maternal and child health, global health, health services research, health policy, and women’s health.  His research focuses on the prenatal and perinatal period as a window of opportunity to improve the long-term health of mothers and their children.  He brings quantitative skills and data analysis expertise to his field of research.

    RESEARCH INTERESTS

    Dr. Meghea’s research focuses on improving women’s health in low resource settings with a collaborative, community-engaged, multidisciplinary, and global approach. The broad goal of this research is to use the prenatal and perinatal period as a window of opportunity to improve the long-term health of women and their families and to reduce health disparities. Dr. Meghea accomplishes this goal by leading clinical and policy relevant health research to improve the care and health of the Medicaid population of pregnant women and by leading interventions focused on tobacco control during and around pregnancy. His research agenda was supported by over $31 million awarded by National Institutes of Health (NIH), Agency for Healthcare Research and Quality (AHRQ), the Romanian Government, Michigan Department of Health and Human Services (MDHHS), the W.K. Kellogg Foundation, and other sources. He is the primary author or co-author of 51 academic articles (close to 650 citations) published in journals including JAMA Pediatrics, American Journal of Preventive Medicine, Pediatrics, American Journal of Public Health, and European Journal of Public Health.

    Dr. Meghea led a research program using quasi-experimental methods that established the Medicaid enhanced prenatal services program in Michigan (MIHP) as an evidence-based program. The analyses relied on multiple complete statewide Medicaid birth cohorts with linked data sources including birth and death records, Medicaid claims, and MIHP program data. The work showed that MIHP participation improves the healthcare utilization of mothers and infants and reduces the risk of adverse birth outcomes and infant mortality. MIHP is now one of the programs that meets the Department of Health and Human Services criteria for an evidence-based home visiting program. Current work includes the evaluation of a Michigan Healthy Start home visiting program in a Pay For Success public-private partnership, with partners including the Michigan Department of Health and Human Services and Spectrum Health, one of five top large health systems in the US. Dr. Meghea is also leading the evaluation of a Michigan Healthy Start program implementing prenatal and postnatal patient safety bundles, as part of a partnership led by the National Healthy Start Association

    Dr. Meghea’s ongoing tobacco control work builds on a program of research in the US and in Romania and includes trials of a phone counseling tobacco cessation intervention, with early evidence of efficacy, and of an app-based mHealth tobacco cessation intervention (the SFT 1.0 app), both focused on pregnant couples, and co-designed with patient, clinical, governmental, non-governmental, and community partners. He uses mixed methods, including advanced research design and evaluation methods in his projects. The mHealth trial uses a factorial design to test main and interaction effects of the intervention components. A 5-year project under review with NIH will test in a hybrid effectiveness/implementation trial the SFT 2.0 tobacco cessation app which incorporates an AI algorithm (reinforcement learning) to continuously optimize the content, flow and cost-effectiveness of the intervention. Dr. Meghea is actively involved in the Society for Research on Nicotine and Tobacco (SRNT), and currently serves as the Public Health Research Director of SRNT-University.

    FUNDING AGENCIES

    National Institutes of Health (NIH), Agency for Health Care Quality (AHRQ), W.K. Kellogg Foundation)

    Publications

    Curriculum Vitae

  • Top researchers speak about the latest scientific research into endometriosis - the challenges, the opportunities, and what discoveries they are hoping to make.

    stacey thumb

    View Full Article

  • Michigan State University researchers, in collaboration with the Van Andel Institute, have identified a combination of two gene mutations that is linked to endometrial cancer.

    Read Full Article on MSUToday

  • 965 Wilson Road, A631B
  • Van Andel Institute 333 Bostwick Ave. NE Room 4024
  •  Hailemariam Debena.Maji

    Biography

    Maji Hailemariam Debena is an assistant professor in the Department of Obstetrics, Gynecology, and Reproductive Biology in the College of Human Medicine. Her research interests include health disparities, mental health, underserved communities including women and justice-involved individuals. Her completed and ongoing research engagements focus on low-resource settings including those low-resource settings within a high-income country context.

    Dr. Hailemariam holds a PhD in mental health epidemiology and a masters degree in social work from Addis Ababa University, Ethiopia. Before joining the Department of Obstetrics, Gynecology, and Reproductive Biology, Dr. Hailemariam completed a postdoctoral program at MSU-Flint, Division of Public Health.

    Research Groups

    Johnson’s research group

    Research Area

    Mental health peer navigation for justice-involved

    Flint Women’s Study

     

  • December 14, 2018

    The Michigan State University Board of Trustees today authorized MSU administration to enter into a Public Private Partnership (P3) for the continued development of the Grand Rapids Research Center (GRRC) site. 

    In July 2018, JLL issued a P3 Request for Proposal (RFP) on behalf of MSU for developer procurement. A lead developer candidate, Health Innovation Partners, a joint venture between MB Real Estate, Walsh Construction/Walsh Investors and Rockford Construction & Development, has been identified and today’s authorization allows MSU administration to proceed with negotiations on the ground lease and developer agreement.

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  • CLIMBING IN RANKING FOR NIH FUNDING

     

Michigan State University’s Department of Obstetrics, Gynecology and Reproductive Biology in the College of Human Medicine has grown in prestige in the number of top researchers it has attracted, as well as garnering more federal grant funding.

  • Ripla Arora PhD

    BIOGRAPHY

    Ripla Arora received her Bachelors and Masters degree in Biochemistry from the University of Delhi, India. She went on to receive her PhD degree in Genetics and Development from Columbia University, New York where she studied the role of T-box transcription factors in vascular morphogenesis of the allantois (umbilical precursor) and epithelial branching in the lung. She completed her postdoctoral work in the Department of Obstetrics Gynecology and Reproductive Sciences at University of California, San Francisco where she developed novel 3D imaging and quantitative modeling of the murine uterus during preimplantation stages and the cycling human endometrium. She is currently an Assistant Professor in the Department of Obstetrics, Gynecology and Reproductive Biology within the College of Human Medicine and a member of the Institute for Quantitative Health Science and Engineering at Michigan State University.

     

    RESEARCH

     

    Abnormalities during the establishment of pregnancy can have impacts far downstream, including miscarriage, placental insufficiency, intra-uterine growth restriction, preeclampsia and preterm birth. Early events of mammalian pregnancy, although crucial for normal development, are poorly understood. Owing to the small size and transparent nature of the early embryo, development from fertilization to blastocyst stages has been extensively documented by imaging. On the other hand deeper understanding of the 3D architecture of the embryo’s uterine environment and the uterine glands has lagged behind. Combining the strengths of developmental genetics, 3D imaging, computational image analysis and gene expression analysis, my laboratory will establish how hormones influence the uterine luminal and glandular epithelium to modulate receptivity and implantation.

    AREAS OF EXPERTISE

    • Uterine Biology -  Maternal Fetal interactions
    • Developmental Genetics
    • Early embryo development

    Publications

    Aroralab.com

    Reproductive and Developmental Sciences

  • The national Stepping Up Initiative is helping hundreds of counties nationwide reduce the number of people with mental illnesses in jails. A Michigan State University professor and her colleague have been awarded a grant to study how the program works and determine what techniques can be adopted to improve treatment for individuals with mental illnesses and keep them out of jail.

    “Our primary goal is to learn more about how county agencies can work together to reduce the number of mentally ill people in county jails,” said Jennifer Johnson, a C.S. Mott Endowed Professor of Public Health at MSU College of Human Medicine. “It’s a chance to learn what works and how we can help counties address these problems.”

    Read Full Article on MSUToday

  • ripla arora wkar

    Ripla Arora is an assistant professor in the Department of Obstetrics, Gynecology, and Reproductive Biology within the College of Human Medicine and is the Chief of the Division of Developmental and Stem Cell Biology in the Institute for Quantitative Health Science and Engineering. Her research focuses on embryo uterine interactions at the time of implantation and uterine development.

    View and Listen to Full Interview