Jose Teixeira PhD


Jose Teixeira, Ph.D. received his B.S. in 1986 from the Massachusetts Institute of Technology and his Ph.D. in 1994 from the University of Massachusetts Medical School in Worcester, MA.  Following his post-doctoral training at the Department of Surgery, at Massachusetts General Hospital and Harvard Medical School in Boston, MA, he was appointed as an Assistant Professor.  He then became an Investigator in the Vincent Center for Reproductive Biology with the rank of Associate Professor in the Department of Obstetrics, Gynecology, and Reproductive Biology at Massachusetts General Hospital and Harvard Medical School.  He was also a Principal Investigator in the Harvard Stem Cell Institute and an affiliate member of both the MGH Cancer Center and the Dana Farber Harvard Cancer Center.  He is currently a Professor in the Department of Obstetrics, Gynecology and Reproductive Biology in the College of Human Medicine at Michigan State University.


We are interested in studying reproductive tract and gonadal developmental with major research interests focused on complementary studies directly related to women's health and reproduction. These include (1) dissecting the signaling mechanisms in the uterus and ovaries and the pathophysiological consequences when they are dysregulated, which we believe might be an underlying cause of uterine fibroid development and gonadal and endometrial cancers; (2) molecular characterization of the subtypes of uterine fibroids with the goal of identifying personalized medicine approaches for women with uterine fibroids; (3) using next generation sequencing approaches to understand the underlying factors that contribute to the racial disparity of the disease in Black women with African American ancestry who have a higher burden of uterine fibroids at an earlier age with increased symptom severity compared to women who are White with European ancestry.  

Jose M. Teixeira, PhD Lab Personnel 


Endometriosis, Adenomyosis and Leiomyomas 

Gynecological Oncology 


  1. George JW, Patterson AL, Tanwar PS, Kajdacsy-Balla A, Prins GS, Teixeira JM. Specific deletion of LKB1/Stk11 in the Müllerian duct mesenchyme drives hyperplasia of the periurethral stroma and tumorigenesis in male mice. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3445-3450. doi: 10.1073/pnas.1612284114. Epub 2017 Mar 13. PMID:28289208
  2. Patterson AL, Pirochta J, Tufano SY, Teixeira JM. Gain-of-function β-catenin in the uterine mesenchyme leads to impaired implantation and decidualization. J Endocrinol. 2017 Apr;233(1):119-130. doi: 10.1530/JOE-16-0502. Epub 2017 Feb 9. PMID:28183999
  3. Gorsic LK, Kosova G, Werstein B, Sisk R, Legro RS, Hayes MG, Teixeira JM, Dunaif A, Urbanek M. Pathogenic Anti-Müllerian Hormone Variants in Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2017 May 12. doi: 10.1210/jc.2017-00612. [Epub ahead of print] PMID: 28505284
  4. Mukherjee A, Patterson AL, George JW, Carpenter T, Madaj ZB, Hostetter G, Risinger JI, and Teixeira JM. "Nuclear PTEN localization contributes to DNA damage repair in Endometrial cancer and could have a diagnostic benefit for therapeutic management of the disease. Mol Cancer Ther. 2018 Sep;17(9):1995-2003. doi: 10.1158/1535-7163.MCT-17-1255. Epub 2018 Jun 13. PMID: 29898896
  5. Patterson AL, George J, Chatterjee A, Carpenter T, Wolfrum E, Pru JK, Teixeira Label-retaining, putative mesenchymal stem cells contribute to repair of the myometrium during uterine involution. Stem Cells Dev. 2018 Oct 17. doi: 10.1089/scd.2018.0146. [Epub ahead of print] PMID: 30328770
  6. Garrel G, Denoyelle C, L'Hôte D, Picard JY, Teixeira J, Kaiser UB, Laverrière JN, Cohen-Tannoudji J. GnRH transactivates human AMH receptor gene via Egr1 and FOXO1 in gonadotrope cells. Neuroendocrinology. 2018 Oct 28. doi: 10.1159/000494890. [Epub ahead of print] PubMed PMID: 30368511
  7. George JW, Fan H, Johnson B, Carpenter TJ, Foy KK, Chatterjee A, Patterson AL, Koeman J, Adams M, Madaj ZB, Chesla D, Marsh EE, Triche TJ, Shen H, Teixeira JM. Integrated Epigenome, Exome, and Transcriptome Analyses Reveal Molecular Subtypes and Homeotic Transformation in Uterine Fibroids. Cell Rep. 2019 Dec 17;29(12):4069-4085.e6. doi: 10.1016/j.celrep.2019.11.077. PubMed PMID: 31851934; PubMed Central PMCID: PMC6956710.
  8. Wilson MR, Reske JJ, Holladay J, Wilber GE, Rhodes M, Koeman J, Adams M, Johnson B, Su RW, Joshi NR, Patterson AL, Shen H, Leach RE, Teixeira JM, Fazleabas AT, Chandler RL.ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion. Nat Commun. 2019 Aug 7;10(1):3554. doi: 10.1038/s41467-019-11403-6. PubMed PMID: 31391455; PubMed Central PMCID: PMC6686004.
  9. Patterson AL, George JW, Chatterjee A, Carpenter TJ, Wolfrum E, Chesla DW, Teixeira JM. Putative human myometrial and fibroid stem-like cells have mesenchymal stem cell and endometrial stromal cell properties. Hum Reprod. 2020 Jan 1;35(1):4457. doi: 10.1093/humrep/dez247. PubMed PMID: 31913469; PubMed Central PMCID: PMC6993861.
  10. Ghosh A, Syed SM, Kumar M, Carpenter TJ, Teixeira JM, Houairia N, Negi S, Tanwar PS.In Vivo Cell Fate Tracing Provides No Evidence for Mesenchymal to Epithelial Transition in Adult Fallopian Tube and Uterus. Cell Rep. 2020 May 12;31(6):107631. doi: 10.1016/j.celrep.2020.107631. PubMed PMID: 32402291.
  11. Wilson MR, Reske JJ, Holladay J, Neupane S, Ngo J, Cuthrell N, Wegener M, Rhodes M, Adams M, Sheridan R, Hostetter G, Alotaibi FT, Yong PJ, Anglesio MS, Lessey BA, Leach RE, Teixeira JM, Missmer SA, Fazleabas AT, Chandler RL. ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation. Cell Rep. 2020 Nov 10;33(6):108366. doi: 10.1016/j.celrep.2020.108366. PubMed PMID: 33176148; PubMed Central PMCID: PMC7682620
  12. Paul EN, Burns GW, Carpenter TJ, Grey JA, Fazleabas AT, Teixeira JMTranscriptome Analyses of Myometrium from Fibroid Patients Reveals Phenotypic Differences Compared to Non-Diseased Myometrium. Int J Mol Sci. 2021 Mar 31;22(7). doi: 10.3390/ijms22073618. PubMed PMID: 33807176; PubMed Central PMCID: PMC8036618
  13. Giuliani E, Schon SB, Yang K, Burns GW, Neff LM, Remmer HA, Teixeira JM, Marsh EE. Obesity-induced follicular phase endometrial proteome dysregulation in a well-phenotyped population. F S Sci. 2022 Jun 13;. doi: 10.1016/j.xfss.2022.06.002. [Epub ahead of print] PubMed PMID: 35710094.
  14. Paul EN, Grey JA, Carpenter TJ, Madaj ZB, Lau KH, Givan SA, Burns GW, Chandler RL, Wegienka GR, Shen H, Teixeira JM. Transcriptome and DNA methylome analyses reveal underlying mechanisms for the racial disparity in uterine fibroids. JCI Insight. 2022 Sep 6:e160274. doi: 10.1172/jci.insight.160274. Epub ahead of print. PMID: 36066972.
  15. Wilson MR, Skalski H, Reske JJ, Wegener M, Adams M, Hostetter G, Hoffmann HM, Bernard JJ, Bae-Jump VL, Teixeira JM, Chandler RL. Obesity alters the mouse endometrial transcriptome in a cell context-dependent manner. Reprod Biol Endocrinol. 2022 Nov 24;20(1):163. doi: 10.1186/s12958-022-01030-0. PMID: 36424602.
  16. Lenis YY, George JW, Lind S, Balboula A, Teixeira JM, Patterson AL. The Effects of Periostin Expression on Fibroid-Like Transition of Myometrial Cells. Reprod Sci. 2022 Nov 23. doi: 10.1007/s43032-022-01128-1. Epub ahead of print. PMID: 36418534.
  17. Kitchen-Goosen SM, Schumacher H, Good J, Patterson AL, Boguslawski EA, West RA, Williams BO, Hostetter G, Agnew DW, Teixeira JM, Alberts AS. Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells. Carcinogenesis. 2022 Dec 22:bgac101. doi: 10.1093/carcin/bgac101. Epub ahead of print. PMID: 36548952.
  18. Wilson MR, Harkins S, Reske JJ, Siwicki RA, Adams M, Bae-Jump VL, Teixeira JM, Chandler RL. PIK3CA mutation in endometriotic epithelial cells promotes viperin-dependent inflammatory response to insulin. Reprod Biol Endocrinol. 2023 May 11;21(1):43. doi: 10.1186/s12958-023-01094-6. PubMed PMID: 37170094; PMCID: PMC10173629.
  19. Paul EN, Carpenter TJ, Fitch S, Sheridan R, Lau KH, Arora R, Teixeira JM. Cysteine-rich intestinal protein 1 is a novel surface marker for human myometrial stem/progenitor cells. Commun Biol. 2023 Jul 3;6(1):686. doi: 10.1038/s42003-023-05061-0. PubMed PMID: 37400623; PMCID: PMC10317972.


  1. Teixeira J, Maheswaran S, and Donahoe, PK. Mullerian inhibiting substance: an instructive developmental hormone with diagnostic and possible therapeutic applications. Endocr Rev (2001) 22: 657-74. PMID11588147
  1. Teixeira J, Rueda BR and Pru JK. Uterine Stem cells (September 30, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.16.1, PMID20614602
  1. Commandeur AE, Styer AC, Teixeira JM. Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth. Hum Reprod Update 2015 Sep;21(5):593-615. doi: 10.1093/humupd/dmv030. Epub 2015 Jul 3. PMID26141720; PMC4533663.


Non-peer reviewed scientific or medical publications/materials in print or other media

  1. Teixeira J and Donahoe PK. Molecular biology of MIS and its receptors. J. Andrology (1996) 17:336-41 PMID8889695
  1. Teixeira J and Lee MM. Gonadogenesis, Male. In: Encyclopedia of Reproduction, (1999) Eds: Knobil E and Neill JD. Academic Press, Orlando, FL, Vol 2 Pg 492-497
  1. MacLaughlin DT, Teixeira J, and Donahoe PK. Perspective: Reproductive tract development-New discoveries and future directions. Endocrinology (2001) 142: 216772. PMID11356658
  2. Lee HJ and Teixeira J. Evidence of a role for androgens in embryonic stem cell function and differentiation. Endocrinology (2008) 149:3-4. PMID18096671
  3. Berin I and Teixeira J. Utility of Serum and Anti-Mullerian Hormone/Mullerian Inhibiting Substance for Predicting Ovarian Reserve in Older Women. Menopause (2008) Sep-Oct;15(5):824-6. PMID18600185
  1. Dubeau L, Teixeira J. Origins of Epithelial Ovarian Cancer (2017) In: Translational Advances in Gynecological Cancers, Eds: Birrer MJ and Ceppi L. Academic Press, Cambridge MA.
  1. Narang K, Cope Z, Teixeira JM. Developmental Genetics in the Female Reproductive Tract (2018) In: Human Reproductive and Prenatal Genetics, Eds: Leung P and Qiao J. Academic Press, Cambridge MA.
  1. Garcia de Paredes J, Strug M, Gosnell J, Cordoba M, Teixeira JM. Developmental Genetics in the Female Reproductive Tract (2023) In: Human Reproductive and Prenatal Genetics 2nd Ed, Eds: Leung P and Qiao J. Academic Press, Cambridge MA.