Dr. Jae Wook Jeong, PhD has received a new National Institute of Health, R01 grant in the amount of $2.65 million for a five year period. The project entitled, “Molecular Mechanisms of Endometrial Progesterone Resistance” will focus on diseases of the female reproductive tract which represent a significant problem in women’s health. To solve these problems, they will try to understand the mechanisms of uterine receptivity and implantation to develop better treatments that may be currently out of reach. Endometrial progesterone resistance implies a decreased responsiveness of target tissue to bioavailable progesterone, and such an impaired progesterone response is seen in the endometrium of women with non-receptive endometrium. However, relatively little is known about the molecular mechanisms and the precise etiology and hormone regulation of endometrial progesterone resistance in female infertility. This NIH R01 project will utilize new genetic model systems to discover and understand these critical mechanisms.