Jeff MacKeigan


Jeff MacKeigan is a Professor in the Department of Obstetrics, Gynecology & Reproductive Biology and Pediatrics & Human Development, and Assistant Dean for Research at the College of Human Medicine. His research focuses on signaling pathways important for cancer cell growth and survival, with the goal of informing new treatment strategies. Dr. MacKeigan received his Ph.D. in Microbiology and Immunology at the University of North Carolina Comprehensive Cancer Center. He completed his postdoctoral training at Harvard Medical School with fellowship funding from the American Cancer Society. Prior to joining MSU, Dr. MacKeigan held positions at Novartis Institutes for Biomedical Research and Van Andel Research Institute.


The MacKeigan Laboratory seeks a “systems level” understanding of the network encompassing cell metabolism, autophagy, and the mTOR signaling pathway, which play a key role in cancer’s therapeutic resistance. Our research involves a variety of technologies, and we use our tumor biology expertise and pathway knowledge to study complex diseases. All of our research projects have one common goal—to identify novel therapeutic targets.


  1. Autophagy
  2. Cancer metabolism
  3. Tuberous sclerosis complex
  4. Chemoresistance
  5. Mitochondria
  6. Kinases, phosphatases



MacKeigan Lab