Jeff MacKeigan


Dr. Jeff MacKeigan is a Professor of Cancer Biology and Complex Diseases in the College of Human Medicine at Michigan State University. He earned his B.A. from the University of Colorado in 1995 and his Ph.D. in Microbiology and Immunology at the University of North Carolina Comprehensive Cancer Center in 2002. His postdoctoral research in the Department of Cell Biology at Harvard Medical School was immediately followed by a position as a project leader at Novartis Institutes for Biomedical Research in Cambridge, Massachusetts in 2004. Dr. MacKeigan joined the faculty at the Van Andel Research Institute as an Assistant Professor in 2006; he was promoted to Associate Professor in 2010; and joined Michigan State University as a Professor in 2017.


The MacKeigan Laboratory seeks a “systems level” understanding of the network encompassing cell metabolism, autophagy, and the mTOR signaling pathway, which play a key role in cancer’s therapeutic resistance. Our research involves a variety of technologies, and we use our tumor biology expertise and pathway knowledge to study complex diseases. All of our research projects have one common goal—to identify novel therapeutic targets.


  1. Autophagy
  2. Cancer metabolism
  3. Tuberous sclerosis complex
  4. Chemoresistance
  5. Mitochondria
  6. Kinases, phosphatases



MacKeigan Lab