MSU

  • Jake Reske is a graduate student at Michigan State University’s biomedical research center in Grand Rapids. He studies Genetics and Genome Sciences in the department of Obstetrics, Gynecology & Reproductive Biology (OBGYN) and works under Dr. Ronald Chandler.

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  • fazleabas v2

    BIOGRAPHY

    Asgi Fazleabas, Ph.D. received his BS degree from California State University, Fresno and His PhD in Reproductive Physiology from the University of Illinois at Urbana - Campaign. Following his post - doctoral training in Reproductive Biology/Cell and Molecular Biology at the University of Florida in Gainesville he joined the Department of Obstetrics and Gynecology at the University of Illinois at Chicago where he held the rank of Professor and Director of Women's Health and Reproduction until October 2009. He is currently Professor and Associate Chair of Research in the Department of Obstetrics, Gynecology and Reproductive Biology and Director of the Center for Women's Health Research and Co-Director of the Reproductive and Developmental Sciences Program at Michigan State University.

    RESEARCH

    Understanding the critical cellular events that define synchrony between the developing embryo and the maternal uterus in a species that is phylogenetically related to humans will be paramount in improving the success of assisted reproductive therapies. Ongoing studies in the Fazleabas' laboratory are at the leading edge of this type of research endeavor. His laboratory was the first to conclusively demonstrate that signals from the primate embryo, like those of other species, induce cell specific changes in uterine gene expression. These changes are thought to play critical roles in establishing a synchrony between the maternal environment and the developing embryo that is a pre requisite for a successful pregnancy. These studies have clearly elucidated the mechanisms by which apoptosis is inhibited within the uterus in the presence of a conceptus, the fundamental hormonal and cellular requirements associated with the process of decidualization and potential functions of uterine proteins in the establishment of pregnancy. The current focus of the work is on the mechanisms by which Notch signaling mediates uterine function during the establishment of pregnancy. A hallmark of all the studies from his laboratory is the ability to confirm all their in vitro findings in vivo as a fundamental application of true physiology in the appropriate tissue context. In addition, his laboratory has established a baboon model for endometriosis. The focus of these studies are to understand the etiology and pathophysiology of Endometriosis, a poorly understood, enigmatic disease that affects five to fifteen percent of all women of reproductive age and has an estimated economic impact of approximately 22 billion dollars in the US. It is reported to be the leading cause of infertility in women. The unique nature of the primate model that he has developed to study endometriosis and the strong multidisciplinary group that he has established has led to important and fundamental findings regarding the causative effects of endometriosis on aberrant gene expression in the eutopic endometrium that may contribute to infertility. Currently the focus is on the role of miRNA’s in regulating cell proliferation and apoptosis and the molecular mechanisms that contribute to progesterone resistance. In addition, the laboratory is also focusing on epigenetic modifications in both endometrial and endometriotic tissues and novel nanoparticle driven therapies to control the disease. Furthermore, studies from the. Fazleabas' laboratory has also identified the genes that may be involved with the process of angiogenesis and cell adhesion during the establishment of lesions in the peritoneal environment.

    Areas of Research:

    Publications

    Asgi Faleabas, PhD Lab Personnel

    GRANTS (Principal Investigator) :


    NICHD RO1 HD 042280 ‚ “Modulation of the Receptive Endometrium by Notch 1” – The overall focus in to understand the cellular and molecular role of Notch1 in the regulation of decidualization and the consequences of its altered expression on fertility as a consequence of gynecological pathologies and reproductive disorders.

    NICHD R21 HD 082453 ‚ “Role of MicroRNA 451 in the Pathophysiology of Endometriosis” – The overall focus is to determine if targeting miRNA 451 in endometriotic lesions could be a useful therapeutic approach for the treatment of endometriosis.

    NICHD RO1 HD 083273 “Role of MicroRNA in the Pathophysiology of Endometriosis” – The overall focus is to understand how specific miRNA’s that are dysregulated in endometriosis and their target genes contribute to altered proliferation, progesterone resistance and fibrosis that could contribute to the development of endometriosis.

    NICHD T32 HD 087166 “Reproductive and Developmental Sciences Training Program” (Co-Director) – This is a comprehensive training program in the reproductive sciences for pre-and post-doctoral fellows at Michigan State University.

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    Endowed Award of Excellence in Obstetrics and Gynecology

    Congratulations to Hope Bauer (MD candidate 2018) who is this year’s recipient of the Bruce Drukker Endowed Award of Excellence in Obstetrics and Gynecology. Hope is a Traverse City CHM student pursuing a career in OB/GYN.

  • Congratulations to Alexandra (Allie) Mahdasian-Miller and Megan Masten, both MD candidate 2019, who are this year’s recipients of the Bruce Drukker Endowed Award of Excellence in Obstetrics and Gynecology.

  • Cara Poland, MD, MEd, Department of Obstetrics, Gynecology and Reproductive Biology, and co-researcher Dawn Goldstein, PhD, RN, were awarded $1,337,280 from the NIH for Increasing Minority Physician and APRN Clinician-scientist Research Training To Equalize Addiction Medicine (IMPACT TEAM) (Aug 2022 - June 2027).

  • Stacey A. Missmer, ScD of Michigan State University Department of Obstetrics, Gynecology, Reproductive Biology is to serve as a member of the Committee on Framework for the Consideration of Chronic Debilitating Conditions in Women.

    The Committee on Framework for the Consideration of Chronic Debilitating Conditions in Women is an ad hoc committee of the National Academies of Sciences, Engineering, and Medicine.  Dr Missmer will serve immediately until September 27, 2024.  

  • Department of Obstetrics, Gynecology, and Reproductive Biology

    965 Wilson Road, Room A626B
    East Lansing, Mi 48824-1316
    (517) 884-6031

    Flint Area Medical Education

    200 East 1st St.
    Flint, Mi 48502

    Grand Rapids Research Center

    400 Monroe Ave. NW
    Grand Rapids, Mi 49503

    Institute for Quantitative Health Science and Engineering

    775 Woodlot Dr, Room A626B
    East Lansing, Mi 48824-1316
    (517) 884-6976
    iq@msu.edu

    Secchia Center

    15 Michigan St. NE
    Grand Rapids, Mi 49503
  • Cristian Meghea PhD

    ABOUT

    Cristian Meghea, Ph.D. is an NIH-funded Associate Professor in the Department of Obstetrics, Gynecology and Reproductive Biology at Michigan State University. He is the Director and Co-Founder of the Maternal Health Equity Lab. His expertise is in maternal and child health, global health, health services research, health policy, and women’s health. His research focuses on the prenatal and perinatal period as a window of opportunity to improve the long-term health of mothers and their children. Trained as an Economist, he brings evaluation and data analysis expertise to his field of research.

    RESEARCH

    Dr. Meghea’s research focuses on improving women’s health in low resource settings with a collaborative, community-engaged, multidisciplinary, and global approach. The broad goal of this research is to use the prenatal and perinatal period as a window of opportunity to improve the long-term health of women and their families and to reduce health disparities. Dr. Meghea accomplishes this goal by leading clinical and policy relevant health research to improve the care and health of the Medicaid population of pregnant women and by leading interventions focused on tobacco control during and around pregnancy. His research agenda was supported by over $21 million awarded by National Institutes of Health (NIH), Agency for Healthcare Research and Quality (AHRQ), the Romanian Government, Michigan Department of Health and Human Services (MDHHS), the W.K. Kellogg Foundation, and other sources. He is the primary author or co-author of 55 academic articles (over 700 citations) published in journals including JAMA Open Network, JAMA Pediatrics, American Journal of Preventive Medicine, Pediatrics, American Journal of Public Health, and European Journal of Public Health.

    Dr. Meghea is leading a 5-year NIH-funded R01 project to develop, implement, and test in a randomized trial a multilevel intervention to address disparities in maternal morbidity and mortality among Medicaid-insured women. Other current work focused on improving the health of Medicaid-

    insured women and infants includes the evaluation of a Michigan Healthy Start home visiting program in a Pay For Success public-private partnership, with partners including the Michigan Department of Health and Human Services and Spectrum Health, one of five top large health systems in the US. Dr. Meghea is also leading the evaluation of a Michigan Healthy Start program implementing prenatal and postnatal patient safety bundles, in a partnership led by the National Healthy Start Association

    Previously, Dr. Meghea led a research program using quasi-experimental methods that established the Medicaid enhanced prenatal services program in Michigan (MIHP) as an evidence-based program. The analyses relied on multiple complete statewide Medicaid birth cohorts with linked data sources including birth and death records, Medicaid claims, and MIHP program data. The work showed that MIHP participation improves the healthcare utilization of mothers and infants and reduces the risk of adverse birth outcomes and infant mortality. MIHP is now one of the programs that meets the Department of Health and Human Services criteria for an evidence-based home visiting program.

    Dr. Meghea’s ongoing tobacco control work builds on a program of research in the US and in Romania and includes completed trials of a phone counseling tobacco cessation intervention and of an app-based mHealth tobacco cessation intervention (the SFT 1.0 app), both focused on pregnant couples, and co-designed with patient, clinical, governmental, non-governmental, and community partners. Both interventions show evidence of feasibility, acceptability, and initial efficacy. He uses mixed methods, including advanced research design and evaluation methods in his projects. The mHealth trial uses a factorial design to test main and interaction effects of the intervention components.

    Dr. Meghea recently secured NIH funding for an up to 5-year project to further develop and test in a hybrid effectiveness/implementation trial the SFT 2.0 tobacco cessation app which incorporates an AI algorithm (reinforcement learning) to continuously optimize the content, flow, and cost-effectiveness of the intervention. Dr. Meghea is actively involved in the Society for Research on Nicotine and Tobacco (SRNT), and currently serves as the Public Health Research Director of SRNT-University.

    FUNDING AGENCIES

    National Institutes of Health (NIH), Agency for Health Care Quality (AHRQ), W.K. Kellogg Foundation)

    Publications

    Curriculum Vitae

  • Detroit Administrative Offices

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    Monica Kole, MD
    Community Clerkship Director
    (313) 916-2454

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    Linda Tillman
    Community Clerkship Assistant
    (313) 916-1449

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    Stasi Mortimore
    Student Programs Administrator
    (313) 693-7896

    Henry Ford Hospital
    3031 West Grand Blvd
    Detroit, MI 48202
  • Dr. Jae Wook Jeong, PhD has received a new National Institute of Health, R01 grant in the amount of $2.65 million for a five year period. The project entitled, “Molecular Mechanisms of Endometrial Progesterone Resistance” will focus on diseases of the female reproductive tract which represent a significant problem in women’s health. To solve these problems, they will try to understand the mechanisms of uterine receptivity and implantation to develop better treatments that may be currently out of reach. Endometrial progesterone resistance implies a decreased responsiveness of target tissue to bioavailable progesterone, and such an impaired progesterone response is seen in the endometrium of women with non-receptive endometrium. However, relatively little is known about the molecular mechanisms and the precise etiology and hormone regulation of endometrial progesterone resistance in female infertility. This NIH R01 project will utilize new genetic model systems to discover and understand these critical mechanisms.

  • Top researchers speak about the latest scientific research into endometriosis - the challenges, the opportunities, and what discoveries they are hoping to make.

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  • Excerpts from our conversation with Dr. Stacey Missmer, an NIH-funded women’s health specialist at Michigan State University.

    NIHNiH: How common are painful periods in teens?

    Missmer: Moderate to severe pain during one’s period—that is, pain that impacts someone's life—is reported by about 35 to 40% of teen and adult women in the U.S. It isn't in any way rare.

  • Wednesday, September 22, 2021

    barnaba

    Carlo Barnaba Ph.D.
    Research Associate,
    Schmidt Lab
    Obstetrics, Gynecology & Reproductive Biology
    Michigan State University

    Presented via Zoom https://msu.zoom.us/j/97602236100
    Meeting ID: 976 0223 6100
    Passcode: OBGYN
    One tap mobile
    +13017158592,,97602236100# US (Germantown)
    +13126266799,,97602236100# US (Chicago)

  • Wednesday, January 25, 2023
    1:00pm – 2:00pm

    https://msu.zoom.us/join

    Gregory Burns, PhD

     

    Postdoctoral Fellow, Fazleabas Lab
    Obstetrics, Gynecology and Reproductive Biology
    Michigan State University

    Grand Rapids Research Center, Rm. 1102


    Optional Zoom
    Zoom Meeting ID: 976 0223 6100
    Passcode: 852200

  • Wednesday, November 9, 2022
    1:00pm – 2:00pm

    Manoj Madhavan

    Manoj Madhavan

    PhD Candidate, Arora Lab
    Department of Biomedical Engineering
    Michigan State University

    Presented via Zoom https://msu.zoom.us/j/97602236100
    Meeting ID: 976 0223 6100
    Passcode: 852200

  • MSU’s new provost, Teresa Woodruff, has recently been named a recipient of one of the Endocrine Society’s 2021 Laureate Awards — top honors that recognize the highest achievements in the endocrinology field.

    Endocrinologists specialize in hormone-related diseases and dedicate their research and clinical care to people with conditions like diabetes, thyroid disorders, obesity, hormone-related cancers, growth problems, osteoporosis and infertility.

    Read on MSUTODAY

  • Wednesday, April 5, 2023
    1:00pm – 2:00pm

    Sue Hammoud

    Sue Hammoud, PhD

    Associate Professor of Human Genetics, Associate Professor of Obstetrics and
    Gynecology, Associate Professor of Urology
    University of Michigan Medical School
    Grand Rapids Research Center, Rm. 1102
    Optional Zoom: https://msu.zoom.us/j/97602236100
    Meeting ID: 976 0223 6100
    Passcode: 852200

  • Join Michigan State University’s outstanding and unique women’s health research program focused on national and international priorities across the life course and discovery in the areas of basic science, clinical and population science, implementation, and translational science at the interface of gynecology and reproductive biology. Be one of a group of diverse new faculty, working in collaboration with MSU’s renowned scholars in a range of scientific, engineering, biomedical, and public health disciplines in an inclusive culture that supports interdisciplinary research and scholarship.

  • Frequently Asked Questions
    (FAQs)

    Thank you for your interest in the W.O.R.K. Study! The study has closed for enrollment. We look forward to sharing more research and educational opportunities in the future.

    Thank you for your time!
    Together, we can make a difference in women’s health.

    Questions?

    Call (616) 234-2858 or email the W.O.R.K. Study team: LetsWork@msu.edu

  • Michigan State University researchers, in collaboration with the Van Andel Institute, have identified a combination of two gene mutations that is linked to endometrial cancer.

    Read Full Article on MSUToday

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