Sascha Drewlo, PhD

Drewlo, Sascha, PhD.
Associate Professor

dr drewlo

BIOGRAPHY

Sascha Drewlo, Ph.D. received his M.Sc. in 2000 from the University of Münster in Germany and his Ph.D. from Germon Sport University, Cologne, Germany in 2006. Following his postdoctoral training at the Lulenfeld Tanenbaum Research Institute, University of Toronto, Canada, he was appointed Assistant Professor in the Department of Obstetrics, Gynecology and Reproductive Biology at Wayne State University.  He has since been awarded the Basil O'Connor Stater Scholar Research Award from 2014 to 2016 in addition to the Gabor Than Award in 2016, which acknowledges outstanding contributions to the field of placentology to an early career investigator. He was then appointed Associate Professor in the Department of Obstetrics, Gynecology and Reproductive Biology at Wayne State University from 2016 to 2017. Dr. Drewlo is currently an Associate Professor in the Department of Obstetrics, Gynecology and Reproductive Biology in the College of Human Medicine at Michigan State University.

RESEARCH

The goal of my research is to close the gap between the diagnosis of placental dysfunction and its treatment. I have interests in the early detection of fetal and placental disorders along with deciphering the underlying molecular mechanisms of abnormal placentation to ultimately develop novel intervention strategies for preeclampsia as well as preterm birth and intrauterine growth restriction.

I furthermore investigate the potential of cervical trophoblast for novel non-invasive fetal diagnosis (Science Translational Medicine, 2016). Our research, and research in collaboration with Dr. Armant at Advanced Reproductive Testing, LLC, develops novel approaches for fetal genetic analysis as well as overall pregnancy status during the first trimester of pregnancy from a simple pap smear. This has the potential to change the way to assess pregnancies as it can be safely performed at as early as 5 weeks.

 

AREAS OF EXPERTISE

  • Human trophoblast cell differentiation
  • Biotechnology
  • Placental Biology
  • Automated Assay Development
  • Early Human Development
  • Fetal Complications

Publications


Deciphering the Role of the Placenta in Abnormal Pregnancies

OUR AIM IS TO...

Provide tools for scientists and clinicians to better identify women and babies at risk for abnormal pregnancy outcomes.

Develop new intervention strategies for patients who suffer from 'poor placentation' to prevent the development of diseases, such as the hypertensive disorder preeclampsia and intra uterine growth restriction.

Close the gap between detection and treatment of high risk pregnancies by combining fundamental placental biology research, with new cutting edge technologies that is highly disruptive and clinically relevant.

We aim to close the gap between the diagnosis and treatment of placental dysfunction. Our research uses a distinctive approach as it combines two innovative methodologies:

  1. Develop a risk assessment methodology to determine the best treatment for patients.
  2. Generate the means to treat the organ that holds the key to successful pregnancy (i.e., the placenta).

This is truly an exciting time for reproductive biology and medicine. This innovative research will provide new, critical insights into early human development and mechanisms of disease. The insights will inform the development of safe and reliable tests to identify women at risk for obstetric complications during pregnancy and help better manage diseases appropriately. We are building upon this unique strength to achieve our ultimate collaborative goal of personalized medicine for every pregnant woman and baby.

Drewlolab.com