Chandler Lab

The long-term goals of Dr. Chandler’s research are to elucidate the molecular and cellular events required to maintain cellular homeostasis in the female reproductive tract and to determine how these processes go awry in inflammation-associated gynecologic diseases and associated cancers. Dr. Chandler’s current research focus involves a SWI/SNF subunit called ARID1A and a newly discovered finding linking ARID1A and PI3-kinase signaling pathway mutations to ovarian tumorigenesis and pro-tumorigenic inflammatory cytokine signaling. Dr. Chandler aims to provide a broader mechanistic understanding of how cells and tissues within the human female reproductive tract cope with repeated cell turnover, stress and inflammation.


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