Asgi Fazleabas, PhD.
Understanding the critical cellular events that define synchrony between the developing embryo and the maternal uterus in a species that is phylogenetically related to humans will be paramount in improving the success of assisted reproductive therapies. Ongoing studies in the Fazleabas laboratory are at the leading edge of this type of research endeavor.
His laboratory was the first to conclusively demonstrate that signals from the primate embryo, like those of other species, induce cell specific changes in uterine gene expression.
These changes are thought to play critical roles in establishing a synchrony between the maternal environment and the developing embryo that is a pre requisite for a successful pregnancy. These studies have clearly elucidated the mechanisms by which apoptosis is inhibited within the uterus in the presence of a conceptus, the fundamental hormonal and cellular requirements associated with the process of decidualization and potential functions of uterine proteins in the establishment of pregnancy. A hallmark of all the studies from his laboratory is the ability to confirm all their in vitro findings in vivo as a fundamental application of true physiology in the appropriate tissue context.