Flint Area Medical EducationGrand Rapids Medical Education & Research CenterKalamazoo Center for Medical StudiesSparrow Health SystemSYNERGY Medical Education AllianceUpper Peninsula Health Education Corporation

Barbara Luke, ScD, MPH

Richard LeachBarbara Luke, ScD, MPH

Professor
Joint appointments in the Department of Obstetrics, Gynecology, and Reproductive Biology and the Department of Epidemiology


A-628 East Fee Hall
517-353-1678
lukeb@msu.edu

Barbara Luke is a reproductive epidemiologist with degrees from Columbia University in nursing and population studies, from New York University in nutrition, and her doctorate from Johns Hopkins University in maternal-child health. During the past fifteen years her research has focused on improving outcomes in multiple births through both clinical and vital statistics research. She is the author, coauthor, or editor of sixteen books, 60 original research papers, and 120 scientific abstracts.  Dr. Luke’s research has been funded from both private foundations and federal sources. Her book, When You’re Expecting Twins, Triplets, or Quads (HarperCollins, 2nd edition, 2004) won Outstanding Book of the Year from the American Society of Journalists and Authors in 2000. She is the recipient of the 2005 Agnes Higgins Award from the March of Dimes for distinguished lifetime achievement in maternal-fetal nutrition

Her primary research focus over the past thirty years has been women’s health, including national and international collaborative studies on employment during pregnancy, perinatal nutrition, and multiple pregnancies. Dr. Luke created the University Consortium on Multiple Births, a group of researchers from universities around the country who collaborate on studies to improve outcomes in multiple pregnancies. She developed and maintains a growing database of more than 3,500 twin, triplet, and quadruplet pregnancies, which began with a decade of twin births in Baltimore, Maryland for her doctoral thesis. Her work over the past 15 years has focused on developing prenatal care standards for multiple pregnancies. Dr. Luke is active at the national level in nutrition and epidemiologic societies, having held elected offices in both the American Dietetic Association and the Society for Pediatric and Perinatal Epidemiology. She is on national and international editorial and advisory boards, and has served as a member of the National Children’s Study.

Grants and Research Projects:
Recent NIH-funded projects include: 1) an evaluation of maternal morbidity and mortality associated with multiple pregnancy in the US using vital statistics data from 1990-2000; and 2) a contemporary evaluation of infant morbidity and mortality risks by plurality using vital statistics data, including the 1995-2000 Matched Multiple Birth Data Set. Nationally, Dr. Luke is collaborating with the Society for Assisted Reproductive Technology (SART) in the development of a series of projects to evaluate the health of men, women, and their children after infertility treatment, including linkage of the SART database with State Birth Defects and Cancer Registries.

Publications (2006-present):

  1. Luke B, Brown MB, Hediger ML, Misiunas RB, Anderson E. Perinatal and early childhood outcomes of twins versus triplets.  Twin Research and Human Genetics 2006; 9:81-88.
  2. Cotter AM, Gonzalez Garcia A, Duthely ML, Luke B, O’Sullivan MJ. Is antiretroviral therapy during pregnancy associated with an increased risk of preterm delivery, low birth weight, or stillbirth? Journal of Infectious Diseases 2006; 193:1195-1201.
  3. Luke B and Brown MB. The changing risk of infant mortality by gestation, plurality, and race: 1989-91 versus 1999-01. Pediatrics 2006; December; 118:2488-2497.
  4. Luke B and Brown MB. Elevated risks of pregnancy complications and adverse outcomes with increasing maternal age. Human Reproduction 2007; May; 22(5):1264-72.
  5. Luke B and Brown MB. The effect of plurality and gestation on the prevention or postponement of infant mortality: 1989-1991 versus 1999-2001. Twin Research and Human Genetics 2007; June, 10:514-520.
  6. Luke B and Brown MB.  Contemporary risks of maternal morbidity and adverse outcomes with increasing maternal age and plurality. Fertility & Sterility 2007; August; 88:283-93.
  7. Luke B and Brown MB. Maternal risk factors for potential maltreatment deaths among healthy singleton and twin infants. Twin Research and Human Genetics 2007; October; 10:778-785.
  8. Luke B and Brown MB. Maternal morbidity and infant mortality in twin versus triplet and quadruplet pregnancies. Am J Obstet Gynecol 2008; 198:401.e1-401.e10.
  9. Manassaran DM, Backer LC, Messing R, Fleming LE, Gomez O, Luke B, Monteilh CP, Flanders D. Assessment of nitrates in drinking water and methemoglobin levels in pregnancy. Environmental Health Perspectives (in press).
  10. Messiah SE, Arheart KL, Luke B, Lipschultz SE, Miller TL. Relationship between body mass index and metabolic syndrome risk factors among US 8 to 14 year olds, 1999-2002. J Peds (in press).
  11. Luke B, Brown MB, Grainger DA, Stern JE, Klein N, Cedars M. The effect of early fetal losses on singleton assisted-conception pregnancy outcomes. Fertil Steril (in press).
  12. Luke B, Brown MB, Grainger DA, Stern JE, Klein N, Cedars M. The effect of early fetal losses on twin assisted-conception pregnancy outcomes. Fertil Steril (in press).
  13. Luke B, Brown MB, Grainger DA, Baker VL, Ginsburg E, Stern JE. The sex-ratio of singleton offspring in assisted-conception pregnancies. Human Reproduction (in press).

Manuscripts in Press

  1. Manassaran DM, Backer LC, Messing R, Fleming LE, Gomez O, Luke B, Monteilh CP, Flanders D. Assessment of nitrates in drinking water and methemoglobin levels in pregnancy. Environmental Health Perspectives.
  2. uke B, Brown MB, Grainger DA, Baker VL, Ginsburg E, Stern JE. The sex-ratio of singleton offspring in assisted-conception pregnancies. Fertility and Sterility. PMID: 18950756
  3. Fujimoto VY, Luke B, Brown MB, Jain T, Armstrong A, Grainger DA, Hornstein M. Racial and Ethnic Disparities in Assisted Reproductive Technology (ART) Outcomes in the United States. Fertility and Sterility. PMID: 19081561
  4. Luke B, Brown MB, Grainger DA, Cedars M, Klein N, Stern JE. Practice patterns and outcomes with the use of single embryo transfer (SET) in the United States. Fertility and Sterility.
  5. Luke B, Brown MB, Grainger DA, Klein N, Stern JE, Cedars M. Effect of embryo transfer number on singleton and twin implantation pregnancy outcomes. Human Reproduction.
  6. Stern JE, Brown MB, Luke B, Wantman E, Lederman A, Missmer SA, Hornstein MD. Calculating cumulative live-birth rates from linked cycles of assisted reproductive technology (ART): Data from the Massachusetts SART CORS. Fertility and Sterility.
  7. Luke B, Brown MB, Morbeck DE, Hudson SB, Coddington CC, Stern JE. Factors associated with ovarian hyperstimulation syndrome (OHSS) and its effect on Assisted Reproductive Technology (ART) treatment and outcome. Fertility and Sterility.
  8. Baker VL, Luke B, Brown MB, Alvero R, Frattarelli JL, Usadi R, Grainger DA, Armstrong AY. Multivariate analysis of factors affecting probability of pregnancy and live birth with in vitro fertilization: An analysis of the SART CORS. Fertility and Sterility.

Chapters in Press

  1. Luke B. Multiple pregnancy, in Symonds M and Ramsay M (editors). Maternal-Fetal Nutrition during Pregnancy and Lactation. London: Cambridge University Press.

Contracts

2009-11 Principal Investigator
National Institutes of Health, NICHD Upstate Kids (Dr. Mary L. Hediger, Intramural Scientist) Infertility Treatment, Child Growth and Development through Age Three Years $151,710

Presentations (2007-present):

  1. Hediger ML, Luke B, Grainger DA, Witter F, Newman R, Gonzalez-Quintero VH. Twin intrapair crown-rump length discordancy and risk of very preterm birth [poster]. 27th annual meeting, Society for Maternal Fetal Medicine, San Francisco, California, February 5-10, 2007.
  2. Luke B,  Hediger ML, Min L, Nugent C, Newman R, Hankins G, Grainger DA. The effect of weight gain by 20 weeks gestation on twin birthweight and postpartum weight [poster]. 27th annual meeting, Society for Maternal Fetal Medicine, San Francisco, California, February 5-10, 2007.
  3. Luke B and Brown MB. Why do healthy babies die? Evaluating the risk of infant death due to abuse by maternal age and plurality [poster]. 20th Annual meeting, Society for Pediatric and Perinatal Epidemiology, Boston, Massachusetts, June 18-19, 2007.
  4. Luke B, Brown MB, Grainger DA, Stern JE, Baker V, Ginsburg E. The sex-ratio of singleton offspring in assisted-conception pregnancies [oral]. 63rd Annual meeting, American Society for Reproductive Medicine, Washington, DC, October 13-17, 2007.
  5. Luke B, Brown MB, Grainger DA, Stern JE, Klein N, Cedars M. The effect of early fetal losses on singleton assisted-conception pregnancy outcomes [oral]. 63rd Annual meeting, American Society for Reproductive Medicine, Washington, DC, October 13-17, 2007.
  6. Luke B, Brown MB, Grainger DA, Stern JE, Klein N, Cedars M. The effect of early fetal losses on twin assisted-conception pregnancy outcomes [oral]. 63rd Annual meeting, American Society for Reproductive Medicine, Washington, DC, October 13-17, 2007.
  7. Lee R, Luke B, Li PS, Schattman G, Goldstein M, Schlegel PN. Changes over time of testicular sperm extraction (TESE) with IVF/ICSI for treatment of male factor infertility [poster]. 63rd Annual meeting, American Society for Reproductive Medicine, Washington, DC, October 13-17, 2007.
  8. Luke B, Brown MB, Gonzalez-Quintero VH. Maternal morbidity and infant mortality in late preterm singleton births: 1989-91 vs 1999-01 [poster].  28th Annual Meeting, Society for Maternal-Fetal Medicine, Dallas, Texas, January 28-February 2, 2008.
  9. Luke B, Brown MB, Gonzalez-Quintero VH. Maternal morbidity and infant mortality in late preterm twin births: 1989-91 vs 1999-01 [poster].  28th Annual Meeting, Society for Maternal-Fetal Medicine, Dallas, Texas, January 28-February 2, 2008.
  10. Luke B, Brown MB, Newman RB, Hankins GDV, Gonzalez-Quintero VH. Association between maternal weight gain, placental weight, and twin birthweight [poster].  Society for Pediatric and Perinatal Epidemiology, Chicago, Illinois, June 23-24, 2008.
  11. Luke B, Brown MB, Morbeck D, Hudson SB, Coddington C, Stern JE. Factors associated with ovarian hyperstimulation syndrome (OHSS) and the effect on assisted reproductive technology (ART) treatment and outcome. 64th Annual meeting, American Society for Reproductive Medicine, November 8-12, 2008, San Francisco, California.
  12. Luke B, Brown MB, Fujimoto VY, Jain T, Armstrong A, Hornstein MD. Ethnic disparities in pregnancy and birth outcomes resulting from the use of assisted reproductive technology (ART) in the United States. 64th Annual meeting, American Society for Reproductive Medicine, November 8-12, 2008, San Francisco, California.
  13. Luke B, Brown MB, Grainger DA, Klein N, Stern JE, Cedars MI. Impact of embryo transfer number on singleton implantation pregnancy outcome. 64th Annual meeting, American Society for Reproductive Medicine, November 8-12, 2008, San Francisco, California.
  14. Luke B, Brown MB, Grainger DA, Klein N, Cedars MI, Stern JE. Characteristics of the the practice patterns and outcomes for use of single embryo transfer (SET) in the United States. 64th Annual meeting, American Society for Reproductive Medicine, November 8-12, 2008, San Francisco, California.